曼思特研发部香加皮科研工作进展

          香加皮中C₂₁甾体糖苷和寡糖的化学研究

   本司研发部对香加皮根中的C₂₁甾体糖苷和寡糖进行系统的植物化学研究，从中分离得到10个C₂₁甾体糖苷和4个寡糖，其中包括4个新的C₂₁甾体糖苷，分别命名为Perisepiumosides F, Perisepiumosides G, Perisepiumosides H和Perisepiumosides I，6个已知的C₂₁甾体糖苷分别为perisepiumoside B, perisepiumoside C, 5-pregnen-3β,20β-diol glucoside, Periplocoside M, Periplocoside N和Periplocoside F，4个已知的寡糖分别为杠柳寡糖B Perisesaccharide B, 杠柳寡糖C Perisesaccharide C, Perisaccharide B和2-O-acetyl-β-D-digitalopyranosyl-(1-4)- β-D-cymaropyranosyl-(1-4)-β-D-cymaropyranosyl-(1-4)-β-D-cymaropyranosyl-(1-4)-β-D-oleandronic-δ-lactone。该研究结果发表在天然产物杂志Fitoterapia上，文章如下：

Xin-Yue Gu, Zhou-Wei Wu, Lun Wang, Fu Li, Bin Chen, Kai Yu, Ming-Kui Wang*. C₂₁ steroidal glycosides and oligosaccharides from the root bark of Periploca sepium, Fitoterapia, 2017, 118: 6-12

香加皮系列部分产品：

A1012       杠柳毒苷;萝蘑毒苷;五加皮苷G   Periplocoside;Periplocin  13137-64-9

A1013       杠柳苷元;杠柳毒苷元;杠柳毒苷苷元  Periplogenin     514-39-6

A1014       杠柳次苷         Periplocymarin         32476-67-8;127-32-2

A1029       异杠柳毒苷;杠柳苷元-3-O-β -葡萄糖（1-4）-β- 箭毒羊角拗糖苷       Periplogenin 3-O-β -glucopyranosyl- (1-4)-β- sarmentopyranoside        1253421-94-1

A1030       杠柳寡糖B      Perisesaccharide B  1095261-93-0

A1031       杠柳寡糖C      Perisesaccharide C  1311473-28-5

A1032       乙酰杠柳寡糖C      Acetyl Perisesaccharide C        110764-09-5

A1033       北五加皮苷M;杠柳苷M       Periplocoside M       116782-73-1

A1034       北五加皮苷N;杠柳苷N         Periplocoside N        39946-41-3